Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | PSMB1 | P20618 | 5/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 4/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7927623 | 0.99 | LTA4H (0.58) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL7918684 | 0.85 | LTA4H (0.59) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL3130426 | 0.81 | LTA4H (0.52) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL7777295 | 0.80 | LTA4H (0.53) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL699174 | 0.75 | ESR1 (0.76) | LTA4HPSMB1PSMB5PSMB2HRH3 | |
| SCHEMBL1359959 | 0.75 | ESR1 (0.76) | LTA4HPSMB1PSMB5PSMB2HRH3 | |
| SCHEMBL8709194 | 0.73 | LTA4H (0.58) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL7141714 | 0.73 | LTA4H (1.00) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL7108553 | 0.73 | KDM4E (0.49) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL2475993 | 0.73 | ESR1 (0.75) | LTA4HPTGS2PTGS1PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729956-B1 | Benzothiophene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-1113013-A1 | Benzothiophene compounds, intermediates, compositions and methods | Eli Lilly & Company (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-0729956-A1 | Benzothiophene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |