Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 13/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.52 |
| ▸ | ESR1 | P03372 | 3/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.49 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3130426 | 0.99 | LTA4H (0.52) | LTA4HPTGS2PTGS1ESR1ESR2 | |
| SCHEMBL7108553 | 0.85 | KDM4E (0.49) | LTA4HPTGS2PTGS1ESR1ESR2 | |
| SCHEMBL7650467 | 0.84 | KDM4E (0.57) | LTA4HPTGS2PTGS1ESR1ESR2 | |
| SCHEMBL7927623 | 0.81 | LTA4H (0.58) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL7918324 | 0.80 | LTA4H (0.57) | LTA4HPTGS2PTGS1PSMB1PSMB5 | |
| SCHEMBL2475993 | 0.76 | ESR1 (0.75) | LTA4HPTGS2PTGS1ESR1ESR2 | |
| SCHEMBL7778580 | 0.75 | LTA4H (0.53) | LTA4HPTGS2PTGS1ESR1PSMB1 | |
| SCHEMBL699174 | 0.75 | ESR1 (0.76) | LTA4HESR1ESR2PSMB1PSMB5 | |
| SCHEMBL1359959 | 0.75 | ESR1 (0.76) | LTA4HESR1ESR2PSMB1PSMB5 | |
| SCHEMBL7443798 | 0.74 | PSMB1 (0.50) | LTA4HESR1ESR2PSMB1PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121125-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2001-08-08 | — | — | EP | claimed |
| WO-2000021535-A1 | PHARMACEUTICAL FORMULATIONS FOR USE IN ESTROGEN DEPRIVATION SYNDROME | ELI LILLY AND COMPANY (US) | 2000-04-20 | — | — | WO | claimed |