Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 2/20 | 0.53 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | CTSA | P10619 | 2/20 | 0.49 |
| ▸ | ACACB | O00763 | 4/20 | 0.47 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.46 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.46 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.46 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.46 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.46 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.46 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.46 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.46 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.46 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | LONP1 | P36776 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3148974 | 0.88 | PSMB5 (0.61) | GRNSORT1OPRM1OPRD1CTSA | |
| SCHEMBL19381926 | 0.88 | PSMB5 (0.61) | GRNSORT1OPRM1OPRD1CTSA | |
| SCHEMBL7921841 | 0.73 | IKBKB (0.41) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL19382404 | 0.73 | PSMB5 (0.53) | ACACBPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL3143565 | 0.73 | PSMB5 (0.53) | ACACBPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL19382408 | 0.71 | CTSS (0.51) | GPR139CTSS | |
| SCHEMBL3144997 | 0.71 | PSMB5 (0.57) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL19381925 | 0.71 | USP30 (0.46) | CTSS | |
| SCHEMBL24283548 | 0.70 | GRN (1.00) | GRNSORT1OPRM1OPRD1CTSA | |
| SCHEMBL24283501 | 0.69 | GRN (0.78) | GRNSORT1OPRM1OPRD1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036357-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-04-01 | — | — | WO | disclosed |