Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | TERT | O14746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12286004 | 0.88 | GAA (0.50) | NAMPTKDM4EPARP1ALDH1A1MAPT | |
| SCHEMBL16255724 | 0.84 | TSHR (0.56) | NAMPTCYP1A2ALOX15KDM4ETSHR | |
| SCHEMBL12142032 | 0.82 | NAMPT (0.49) | NAMPTCYP1A2CYP2C19ALOX15TERT | |
| SCHEMBL12139837 | 0.82 | NAMPT (0.49) | NAMPTCYP1A2CYP2C19ALOX15KDM4E | |
| SCHEMBL7914538 | 0.77 | BLM (0.41) | NAMPTMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL2606198 | 0.77 | MEN1 (0.40) | NAMPTMEN1KMT2A | |
| SCHEMBL23210827 | 0.75 | CYP1A2 (0.46) | NAMPTCYP1A2CYP2C19ALOX15TERT | |
| SCHEMBL8916285 | 0.75 | ALOX15 (0.51) | NAMPTCYP1A2ALOX15KDM4EMEN1 | |
| SCHEMBL17888228 | 0.74 | NAMPT (0.49) | NAMPTCYP1A2MEN1KMT2AMAPT | |
| SCHEMBL17888232 | 0.74 | MEN1 (0.44) | NAMPTMEN1TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889706-B2 | Soluble mTOR complexes and modulators thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-11-18 | — | — | US | disclosed |
| WO-2010044885-A2 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2010-04-22 | — | — | WO | disclosed |