Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.68 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GPR174 | Q9BXC1 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | KLK14 | Q9P0G3 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904829 | 0.88 | THRB (0.66) | KDRTHRBMAPTGAAMAPK1 | |
| SCHEMBL7918619 | 0.88 | THRB (0.69) | KDRTHRBMAPTGAAMAPK1 | |
| SCHEMBL7912171 | 0.86 | KDR (0.62) | KDRTHRBMAPTGAAMAPK1 | |
| SCHEMBL7918511 | 0.86 | MAPT (0.65) | KDRTHRBMAPTGAAMAPK1 | |
| SCHEMBL7914872 | 0.83 | THRB (0.64) | KDRTHRBMAPTGAAMAPK1 | |
| SCHEMBL7912098 | 0.83 | THRB (0.64) | KDRTHRBMAPTGAAMAPK1 | |
| SCHEMBL7913339 | 0.81 | THRB (0.62) | KDRTHRBMAPTGAAMAPK1 | |
| SCHEMBL7912029 | 0.79 | NPSR1 (0.72) | KDRTHRBGAANPSR1ENPP3 | |
| SCHEMBL7913372 | 0.78 | KDR (0.72) | KDRTHRBMAPTGAAGPR174 | |
| SCHEMBL7918550 | 0.78 | THRB (0.58) | KDRTHRBMAPTGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207666-B1 | TREATING PRECANCEROUS LESIONS BY ADMINISTERING 4-PHENYLPHTHALAZINE DERIVATIVE | CELL PATHWAYS, INC. | 2001-03-27 | — | — | US | disclosed |