Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 10/20 | 0.43 |
| ▸ | TUBB | P07437 | 10/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 10/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 10/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 10/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 10/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 10/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 10/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 10/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 10/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 10/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 10/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 10/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 10/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 10/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456933 | 0.86 | BACE1 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7457025 | 0.78 | MGAM (0.45) | MAOBMAPTNPSR1ALDH1A1MAPK1 | |
| SCHEMBL7927647 | 0.76 | FYN (0.40) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7926784 | 0.74 | BACE1 (0.46) | MAOBCNR1CNR2ERN1MAPT | |
| SCHEMBL6594759 | 0.73 | LTA4H (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7930055 | 0.71 | GAA (0.45) | MAPTCYP1A2NPSR1ALDH1A1MAPK1 | |
| SCHEMBL5368387 | 0.70 | MAOB (0.54) | MAOBCNR1CNR2ERN1MAPT | |
| SCHEMBL7501599 | 0.69 | MAOB (0.53) | MAOBCNR1CNR2ERN1MAPT | |
| SCHEMBL7918752 | 0.68 | TUBB4A (0.37) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7927596 | 0.68 | NPSR1 (0.47) | MAOBMAPTNPSR1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729956-B1 | Benzothiophene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-1113013-A1 | Benzothiophene compounds, intermediates, compositions and methods | Eli Lilly & Company (US) | 2001-07-04 | — | — | EP | disclosed |
| US-6197790-B1 | OSTEOPOROSIS | ELI LILLY AND COMPANY | 2001-03-06 | — | — | US | disclosed |
| US-6030986-A | POST-MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION; ESTROGEN INDUCED UTERINE CANCER; OSTEOPOROSIS; RESTENOSIS; CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998441-A | ANTICHOLESTEROL AGENT; MIXTURE WITH ESTROGEN | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5986109-A | UROGENITAL DISORDERS, CARDIOVASCULAR DISORDERS AND ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 1999-11-16 | — | — | US | disclosed |
| US-5985898-A | INHIBITING HYPERLIPIDEMIA RESULTED FROM ESTROGEN DEFICIENCY DISEASE, REDUCING SERUM CHOLESTEROL, | ELI LILLY AND COMPANY (US) | 1999-11-16 | — | — | US | disclosed |
| US-5981765-A | FOR TREATMENT OF POST-MENOPAUSAL SYNDROME INCLUDING OSTEOPOROSIS, CARDIOVASCULAR EFFECTS SUCH AS HYPERLIPIDEMIA, AND ESTROGEN-DEPENDENT CANCER, PARTICULARLY BREAST AND UTERINE CANCER | ELI LILLY AND COMPANY (US) | 1999-11-09 | — | — | US | disclosed |
| US-5977093-A | INHIBITING ESTROGEN-DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| US-5969142-A | OXIDIZING SULFUR ATOM OF SUBSTITUTED BENZOTHIOPHENE, REACTING PRODUCT WITH NUCLEOPHILIC GROUP, REDUCING PRODUCT TO DESIRED COMPOUND | ELI LILLY AND COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0729956-A1 | Benzothiophene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5492922-A | PREVENTING RESTENOSIS | ELI LILLY AND COMPANY (US) | 1996-02-20 | — | — | US | disclosed |
| US-5488058-A | UROGENITAL DISORDERS OR OSTEOPOROSIS | ELI LILLY AND COMPANY (US) | 1996-01-30 | — | — | US | disclosed |