Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | PDE1A | P54750 | 1/20 | 0.54 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10859893 | 0.97 | SIRT1 (0.61) | ADORA1ADORA2ASIRT1SIRT3SIRT5 | |
| SCHEMBL10856971 | 0.97 | SIRT1 (0.61) | ADORA1ADORA2ASIRT1SIRT3SIRT5 | |
| SCHEMBL11072524 | 0.94 | SIRT1 (0.55) | ADORA1ADORA2AADORA3ADORA2BSIRT1 | |
| SCHEMBL1063544 | 0.90 | SIRT1 (0.68) | ADORA1ADORA2AADORA3ADORA2BSIRT1 | |
| SCHEMBL11066305 | 0.90 | SIRT1 (0.54) | ADORA1ADORA2AADORA3ADORA2BSIRT1 | |
| SCHEMBL10855008 | 0.89 | ADORA2A (0.49) | ADORA1ADORA2AADORA3ADORA2BSIRT1 | |
| SCHEMBL4953015 | 0.88 | ADORA2B (0.52) | ADORA1ADORA2AADORA3ADORA2BSIRT1 | |
| SCHEMBL10861347 | 0.87 | PDE2A (0.54) | ADORA1ADORA2AADORA3ADORA2BSIRT1 | |
| SCHEMBL9430619 | 0.87 | ADORA2A (0.61) | ADORA1ADORA2AADORA3ADORA2BSIRT1 | |
| SCHEMBL1462066 | 0.86 | PDE2A (0.46) | ADORA1ADORA2AADORA3ADORA2BSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221874-B1 | 7-CYCLIC-SUBSTITUTED SULFONYL-3,7-DIHYDRO-PURINE-2, 6-DIONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION | 2001-04-24 | — | — | US | disclosed |
| EP-0708781-A1 | A 3 ADENOSINE RECEPTOR AGONISTS | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) | 1996-05-01 | — | — | EP | disclosed |