Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 13/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911453 | 0.80 | HTR1A (0.76) | HTR1ASLC6A4DRD2HTR2AHTR6 | |
| SCHEMBL31285862 | 0.76 | MAPT (0.60) | HTR1AKDM4ELMNAALOX15SLC6A4 | |
| SCHEMBL7916133 | 0.76 | MAPT (0.60) | HTR1AKDM4ELMNAALOX15SLC6A4 | |
| SCHEMBL7121698 | 0.75 | HTR1A (0.71) | HTR1AKDM4ELMNAALOX15SLC6A4 | |
| SCHEMBL7911460 | 0.75 | HTR1A (1.00) | HTR1AKDM4ELMNAALOX15SLC6A4 | |
| SCHEMBL7215901 | 0.73 | HTR1D (0.51) | HTR1ASLC6A4DRD2HTR2AHTR6 | |
| SCHEMBL5845471 | 0.73 | HTR1A (0.63) | HTR1AKDM4ELMNAALOX15SLC6A4 | |
| SCHEMBL6970489 | 0.72 | MAPT (0.64) | HTR1ALMNAHTTPOLB | |
| SCHEMBL6964820 | 0.72 | HTR1A (0.61) | HTR1AKDM4ELMNAALOX15DRD2 | |
| SCHEMBL5843988 | 0.71 | HTR1A (0.63) | HTR1AKDM4ELMNAALOX15SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221863-B1 | TREATING DEPRESSION IN A PATIENT | AMERICAN HOME PRODUCTS CORP. | 2001-04-24 | — | — | US | disclosed |
| WO-2000040581-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |