Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.61 |
| ▸ | DRD2 | P14416 | 5/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9678810 | 0.84 | SIGMAR1 (0.74) | SIGMAR1 | |
| SCHEMBL6969178 | 0.79 | SIGMAR1 (0.57) | HTR1ADRD2SIGMAR1HTR2A | |
| SCHEMBL6966928 | 0.79 | SIGMAR1 (0.57) | HTR1ADRD2SIGMAR1HTR2A | |
| SCHEMBL5845471 | 0.77 | HTR1A (0.63) | HTR1ADRD2HTR2ADRD1DRD3 | |
| SCHEMBL6966093 | 0.77 | SIGMAR1 (0.70) | SIGMAR1 | |
| SCHEMBL9844439 | 0.75 | SIGMAR1 (0.62) | SIGMAR1KDM4EALOX15 | |
| SCHEMBL6953909 | 0.75 | SIGMAR1 (0.69) | SIGMAR1 | |
| SCHEMBL7214414 | 0.74 | HTR1A (0.62) | HTR1ADRD2HTR2ADRD1DRD3 | |
| SCHEMBL9678912 | 0.74 | SIGMAR1 (0.59) | HTR1ADRD2SIGMAR1DRD3 | |
| SCHEMBL7121689 | 0.73 | HTR1A (0.61) | HTR1ADRD2HTR2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964863-B1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 2003-05-21 | — | — | EP | disclosed |
| US-6462056-B1 | SUCH AS 3-(4-CHLOROPHENYL)-5-(4-(3-INDOLYL)-1-PIPERIDINYL-METHYL)OXAZOLIDIN-2-ONE; 5-HT2A ANTAGONISTS WITH 5-HT REUPTAKE INHIBITING, ANTIDEPRESSANT OR ANXIOLYTIC EFFECT | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2002-10-08 | — | — | US | disclosed |
| EP-0964863-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GmbH (DE) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998038189-A1 | OXAZOLIDINES AS 5-HT2A-ANTAGONISTS | MERCK PATENT GMBH (DE) | 1998-09-03 | — | — | WO | disclosed |