SCHEMBL7919347

SCHEMBL7919347

Cc1cc(N2N=CCNC2=O)cc(Cl)c1C(C#N)c1ccc(Cl)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
NR1I2 O75469 1/20 0.47
FPR2 P25090 1/20 0.33
PROKR1 Q8TCW9 1/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
LMNA P02545 2/20 0.33
POLB P06746 2/20 0.33
ALDH1A1 P00352 2/20 0.33
GAA P10253 1/20 0.32
CYP3A4 P08684 2/20 0.32
MAPK1 P28482 2/20 0.32
BLM P54132 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
SLC22A1 O15245 1/20 0.32
EGFR P00533 1/20 0.32
ERBB2 P04626 1/20 0.32
LCK P06239 1/20 0.32
FYN P06241 1/20 0.32
ADORA3 P0DMS8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7838454 0.92 MEN1 (0.54) MEN1KMT2ANR1I2FPR2PROKR1
SCHEMBL7917025 0.88 MEN1 (0.38) MEN1KMT2ANR1I2
SCHEMBL7917757 0.85 FPR2 (0.33) MEN1KMT2ANR1I2FPR2PROKR1
SCHEMBL7917510 0.80 MEN1 (0.34) MEN1KMT2ANR1I2FPR2PROKR1
SCHEMBL7919693 0.78 MEN1 (0.34) MEN1KMT2ANR1I2FPR2PROKR1
SCHEMBL7917049 0.78 MEN1 (0.34) MEN1KMT2ANR1I2FPR2PROKR1
SCHEMBL7919178 0.78 KMT2A (0.52) MEN1KMT2ANR1I2FPR2PROKR1
SCHEMBL7917055 0.77 MEN1 (0.35) MEN1KMT2ANR1I2
SCHEMBL7919364 0.77 MEN1 (0.46) MEN1KMT2ANR1I2FPR2PROKR1
SCHEMBL7919224 0.76 MEN1 (0.33) MEN1KMT2ANR1I2L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211178-B1 ANTIPROTOZOA AGENTS FOR COCCIDIOIDES; CYCLIZATION TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-04-03 US disclosed
US-5994355-A ANTIPROTOZOA AGENTS, PARASITICIDE; VETERINARY MEDICINE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-11-30 US disclosed
EP-0648760-B1 Triazine derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1999-01-27 EP disclosed
EP-0648760-A2 Triazine derivative, production and use thereof TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-04-19 EP disclosed