Torin1

Torin1

SCHEMBL7919574

CCC(=O)N1CCN(c2ccc(-n3c(=O)ccc4cnc5ccc(-c6cnc7ccccc7c6)cc5c43)cc2C(F)(F)F)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MTOR P42345 16/20 1.00
PIK3C2A O00443 2/20 1.00
PIK3C2B O00750 2/20 1.00
PIK3CA P42336 2/20 1.00
PIK3CG P48736 2/20 1.00
PIK3C3 Q8NEB9 2/20 1.00
PI4KB Q9UBF8 2/20 1.00
PIK3CD O00329 1/20 1.00
PIK3R1 P27986 1/20 1.00
PRKDC P78527 1/20 1.00
CDC42BPA Q5VT25 1/20 1.00
RICTOR Q6R327 1/20 1.00
RPTOR Q8N122 1/20 1.00
MAPKAP1 Q9BPZ7 1/20 1.00
MLST8 Q9BVC4 1/20 1.00
PIK3CB P42338 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Torin1 SCHEMBL29350222 1.00 MTOR (1.00) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
Torin1 SCHEMBL29357575 1.00 MTOR (1.00) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
Torin1 SCHEMBL29499920 1.00 MTOR (1.00) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
SCHEMBL6876203 0.95 MTOR (0.91) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
SCHEMBL6878217 0.93 MTOR (0.87) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
SCHEMBL7919237 0.92 MTOR (1.00) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
SCHEMBL6874967 0.91 MTOR (1.00) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
SCHEMBL6877194 0.91 MTOR (0.84) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
SCHEMBL6877181 0.91 MTOR (0.86) MTORPIK3C2APIK3C2BPIK3CAPIK3CG
SCHEMBL6874774 0.91 MTOR (1.00) MTORPIK3C2APIK3C2BPIK3CAPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 107 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023196676-A1 TREATING TUBEROUS SCLEROSIS COMPLEX-ASSOCIATED DISEASES THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2023-10-12 WO claimed
WO-2023073054-A1 COMPOSITIONS AND METHODS USING AN AUTOPHAGY INDUCER TO ENHANCE INTERMITTENT FASTING Société des Produits Nestlé S.A. (CH) 2023-05-04 WO claimed
US-11471462-B2 Compositions and methods for detecting and treating diabetes THE BROAD INSTITUTE, INC. (US) 2022-10-18 US claimed
EP-4729121-A2 NOVEL COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DERMAL DISORDERS Drexel University (US) 2026-04-22 EP disclosed
EP-3352755-B1 TOPICAL COMPOSITION COMPRISING RAPAMYCIN FOR USE IN TREATING OR PREVENTING SEBORRHEIC KERATOSIS OR ACTINIC KERATOSIS UNIV DREXEL (US) 2025-12-24 EP disclosed
US-20250333479-A1 NOVEL FUSION MOLECULES AND USES THEREOF FOUNDATION MEDICINE, INC. (US) 2025-10-30 US disclosed
US-20250333480-A1 FUSION MOLECULES AND USES THEREOF FOUNDATION MEDICINE, INC. (US) 2025-10-30 US disclosed
US-12378302-B2 Fusion molecules and uses thereof FOUNDATION MEDICINE, INC. (US) 2025-08-05 US disclosed
US-20240382614-A1 Self-Assembling Nanoparticles Based On Amphiphilic Peptides for Drug Delivery Applications BARINTHUS BIOTHERAPEUTICS NORTH AMERICA, INC. (US) 2024-11-21 US disclosed
US-20240325398-A1 COMBINATION THERAPIES INFINITY PHARMACEUTICALS, INC. 2024-10-03 US disclosed
US-20240207270-A1 COMPOUNDS AND COMPOSITIONS FOR MODULATING LIPID METABOLISM WAVEBREAK INC (US) 2024-06-27 US disclosed
US-20130072485-A1 SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2013-03-21 US disclosed
US-20130072485-A1 SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF DANA-FARBER CANCER INSTITUTE, INC. (US) 2013-03-21 US disclosed
US-8394818-B2 Soluble mTOR complexes and modulators thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2013-03-12 US disclosed
US-8394818-B2 Soluble mTOR complexes and modulators thereof DANA-FARBER CANCER INSTITUTE, INC. (US) 2013-03-12 US disclosed
US-20120190676-A1 INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS MOORMAN NATHANIEL (US) 2012-07-26 US disclosed
US-20120190676-A1 INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS MOORMAN NATHANIEL (US) 2012-07-26 US disclosed
US-20110288091-A1 SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2011-11-24 US disclosed
US-20110288091-A1 SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2011-11-24 US disclosed
WO-2010044885-A2 SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) 2010-04-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120190676-A1 INHIBITORS OF MTOR KINASE AS ANTI-VIRAL AGENTS EIF2AK2, MTOR, EIF4EBP1 MTOR 2/4885PIK3C2A 271/4885PIK3C2B 329/4885
US-20240382614-A1 Self-Assembling Nanoparticles Based On Amphiphilic Peptides for Drug Delivery Applications ANXA11, ANXA1, IAPP MTOR 4558/4885PIK3C2A 2212/4885PIK3C2B 1889/4885
US-20130072485-A1 SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885PIK3C2A 18/4885PIK3C2B 16/4885
US-11471462-B2 Compositions and methods for detecting and treating diabetes SLC2A2, SLC2A1, SLC5A2 MTOR 3599/4885PIK3C2A 2622/4885PIK3C2B 2870/4885
US-12378302-B2 Fusion molecules and uses thereof RPS27A, CD2BP2, FGB MTOR 4841/4885PIK3C2A 2442/4885PIK3C2B 1892/4885
US-20250333479-A1 NOVEL FUSION MOLECULES AND USES THEREOF RPS27A, CD2BP2, FGB MTOR 4823/4885PIK3C2A 1969/4885PIK3C2B 1450/4885
US-20240207270-A1 COMPOUNDS AND COMPOSITIONS FOR MODULATING LIPID METABOLISM CPT2, PC, SREBF2 MTOR 426/4885PIK3C2A 673/4885PIK3C2B 603/4885
US-20110288091-A1 SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF MTOR, RICTOR, RPTOR MTOR 1/4885PIK3C2A 18/4885PIK3C2B 16/4885
US-20240325398-A1 COMBINATION THERAPIES HDAC1, HDAC4, HDAC2 MTOR 24/4885PIK3C2A 108/4885PIK3C2B 119/4885
US-20250333480-A1 FUSION MOLECULES AND USES THEREOF RPS27A, CD2BP2, FGB MTOR 4841/4885PIK3C2A 2442/4885PIK3C2B 1892/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.