Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 7/20 | 0.53 |
| ▸ | DRD5 | P21918 | 4/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919596 | 0.85 | DRD1 (0.67) | CYP3A4CYP2D6DRD1DRD5MEN1 | |
| SCHEMBL9405364 | 0.75 | DRD1 (0.59) | CYP3A4CYP2D6DRD1DRD5 | |
| SCHEMBL2574136 | 0.75 | SIRT6 (0.57) | DRD1DRD5SIRT6MEN1KMT2A | |
| SCHEMBL9764189 | 0.75 | DRD1 (0.59) | CYP3A4CYP2D6DRD1DRD5MEN1 | |
| SCHEMBL7922430 | 0.74 | DRD1 (0.55) | CYP3A4CYP2D6DRD1DRD5MEN1 | |
| SCHEMBL9404237 | 0.73 | CYP3A4 (0.39) | CYP3A4CYP2D6DRD1DRD5CA1 | |
| SCHEMBL9839693 | 0.72 | DRD1 (0.72) | CYP3A4CYP2D6DRD1DRD5MEN1 | |
| SCHEMBL9839699 | 0.72 | DRD1 (0.72) | CYP3A4CYP2D6DRD1DRD5MEN1 | |
| Trepipam SCHEMBL11704977 | 0.71 | CYP2D6 (1.00) | CYP3A4CYP2D6DRD1DRD5MEN1 | |
| Trepipam SCHEMBL29374758 | 0.71 | CYP2D6 (1.00) | CYP3A4CYP2D6DRD1DRD5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211173-B1 | Use of 2,3,4,5-tetrahydro-1H-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders | CENES LIMITED (GB) | 2001-04-03 | — | — | US | disclosed |
| EP-1011679-A1 | USE OF 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP DISORDERS | CeNes Limited (GB) | 2000-06-28 | — | — | EP | disclosed |
| WO-1998040072-A1 | USE OF 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF SLEEP DISORDERS | CENES LIMITED (GB) | 1998-09-17 | — | — | WO | disclosed |
| EP-0347672-B1 | Benzazepine derivatives | NOVO NORDISK AS (DK) | 1994-03-02 | — | — | EP | disclosed |
| US-5025009-A | Treatment of central nervous system disorders; bioavailability | NOVO NORDISK A/S (DK) | 1991-06-18 | — | — | US | disclosed |
| US-5010074-A | Treating CNS disorders; dopamine antagonist; bioavailability | NOVO NORDISK A/S (DK) | 1991-04-23 | — | — | US | disclosed |
| EP-0347672-A1 | Benzazepine derivatives | NOVO NORDISK A/S (DK) | 1989-12-27 | — | — | EP | disclosed |