Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 14/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | DRD5 | P21918 | 8/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18085059 | 0.85 | SLC6A2 (0.76) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL11393016 | 0.85 | SLC6A2 (0.76) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL7919382 | 0.82 | DRD1 (0.72) | DRD1DRD5DRD2DRD3DRD4 | |
| SCHEMBL3663433 | 0.78 | DRD1 (0.65) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL12151317 | 0.77 | DRD1 (0.58) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL17993845 | 0.76 | SIGMAR1 (0.56) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL7919604 | 0.75 | CYP3A4 (0.55) | DRD1DRD5CYP3A4CYP2D6 | |
| SCHEMBL14502337 | 0.74 | DRD1 (1.00) | DRD1DRD5DRD2CYP3A4CYP2D6 | |
| SCHEMBL3665562 | 0.73 | CA1 (0.53) | DRD1SLC6A2SLC6A4SLC6A3DRD5 | |
| SCHEMBL4035754 | 0.71 | SLC6A2 (1.00) | DRD1SLC6A2SLC6A4SLC6A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347672-B1 | Benzazepine derivatives | NOVO NORDISK AS (DK) | 1994-03-02 | — | — | EP | disclosed |
| US-5025009-A | Treatment of central nervous system disorders; bioavailability | NOVO NORDISK A/S (DK) | 1991-06-18 | — | — | US | disclosed |
| US-5010074-A | Treating CNS disorders; dopamine antagonist; bioavailability | NOVO NORDISK A/S (DK) | 1991-04-23 | — | — | US | disclosed |
| EP-0347672-A1 | Benzazepine derivatives | NOVO NORDISK A/S (DK) | 1989-12-27 | — | — | EP | disclosed |