SCHEMBL7919685

SCHEMBL7919685

O=C(CCCCCn1cc(C(=O)Nc2ccncc2)c(=O)c2cc(F)ccc21)NO

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 12/20 0.47
HDAC6 Q9UBN7 12/20 0.47
HDAC3 O15379 7/20 0.47
HDAC2 Q92769 7/20 0.47
HDAC4 P56524 6/20 0.47
HDAC7 Q8WUI4 5/20 0.47
HDAC10 Q969S8 5/20 0.47
HDAC11 Q96DB2 5/20 0.47
HDAC8 Q9BY41 5/20 0.47
HDAC9 Q9UKV0 5/20 0.47
HDAC5 Q9UQL6 5/20 0.47
MAPT P10636 2/20 0.46
RXFP1 Q9HBX9 1/20 0.46
BRD4 O60885 1/20 0.44
NCOR2 Q9Y618 1/20 0.44
CNR2 P34972 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3467960 0.93 HDAC1 (0.51) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3467644 0.91 HDAC1 (0.52) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3467582 0.89 HDAC1 (0.55) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL7917237 0.87 HDAC1 (0.56) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3467092 0.87 CNR2 (0.46) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3467448 0.87 GAA (0.54) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3467867 0.85 MAPT (0.50) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3467483 0.83 GAA (0.60) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3467463 0.83 CNR2 (0.58) HDAC1HDAC6HDAC3HDAC2HDAC4
SCHEMBL3468901 0.81 HDAC1 (0.48) HDAC1HDAC6HDAC3HDAC2HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010073078-A2 HETEROCYCLIC COMPOUNDS AS HDAC INHIBITORS ORCHID RESEARCH LABORATORIES LTD. (IN) 2010-07-01 WO disclosed