Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCE | Q02156 | 4/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 4/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.36 |
| ▸ | PRKCG | P05129 | 3/20 | 0.36 |
| ▸ | PRKCB | P05771 | 3/20 | 0.36 |
| ▸ | PRKCA | P17252 | 3/20 | 0.36 |
| ▸ | PRKCH | P24723 | 3/20 | 0.36 |
| ▸ | PRKCI | P41743 | 3/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | PRKACA | P17612 | 2/20 | 0.32 |
| ▸ | PRKACG | P22612 | 2/20 | 0.32 |
| ▸ | PRKACB | P22694 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908979 | 0.73 | CNR1 (0.38) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL2909759 | 0.72 | CNR1 (0.50) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL2908972 | 0.72 | CYP3A4 (0.64) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL2909739 | 0.69 | ROCK2 (0.47) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL23795402 | 0.67 | PRKCD (0.57) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL30439363 | 0.67 | PRKCD (0.57) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL30439459 | 0.67 | PRKCD (0.57) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL23795296 | 0.67 | PRKCD (0.57) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| SCHEMBL13513879 | 0.67 | PRKCD (0.65) | PRKCEPRKCDPRKD1ROCK2PRKX | |
| Hydrochloric Acid SCHEMBL23795335 | 0.67 | PRKCD (0.58) | PRKCEPRKCDPRKD1ROCK2PRKX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218410-B1 | ADMINISTERING A PHARMACEUTICALLY EFFECTIVE AMOUNT OF A RHO KINASE INHIBITOR COMPRISING AMIDE COMPOUND FOR INHIBITING RHO KINASE | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-04-17 | — | — | US | disclosed |