SCHEMBL7920622

SCHEMBL7920622

ON=Cc1c(C(F)(F)F)ccc(Cl)c1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPFFR2 Q9Y5X5 3/20 0.39
NPFFR1 Q9GZQ6 2/20 0.39
HTR3E A5X5Y0 1/20 0.37
HTR3B O95264 1/20 0.37
HTR3A P46098 1/20 0.37
HTR3D Q70Z44 1/20 0.37
HTR3C Q8WXA8 1/20 0.37
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
ESR1 P03372 1/20 0.35
CA9 Q16790 1/20 0.35
ESR2 Q92731 1/20 0.35
KMT2A Q03164 1/20 0.35
KDR P35968 1/20 0.33
CLCN2 P51788 1/20 0.33
NOTUM Q6P988 2/20 0.32
PDK1 Q15118 1/20 0.30
HPGD P15428 1/20 0.30
HTT P42858 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8169905 1.00 NPFFR2 (0.39) NPFFR2NPFFR1HTR3EHTR3BHTR3A
SCHEMBL7926477 0.84 NPFFR1 (0.35) NPFFR2NPFFR1CA12CA1CA2
SCHEMBL7926472 0.84 NPFFR1 (0.35) NPFFR2NPFFR1CA12CA1CA2
SCHEMBL5806845 0.84 NPFFR2 (0.38) NPFFR2NPFFR1HTR3EHTR3BHTR3A
SCHEMBL5806842 0.84 NPFFR2 (0.38) NPFFR2NPFFR1HTR3EHTR3BHTR3A
SCHEMBL24106839 0.79 TDP1 (0.40) NPFFR2NPFFR1KMT2AHTT
SCHEMBL5803125 0.78 CA12 (0.42) CA12CA1CA2ESR1CA9
SCHEMBL5803124 0.78 CA12 (0.42) CA12CA1CA2ESR1CA9
SCHEMBL7927635 0.76 ALDH1A1 (0.40) NPFFR2NPFFR1HTR3EHTR3BHTR3A
SCHEMBL10518873 0.76 CA12 (0.38) CA12CA1CA2ESR1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0847977-B1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO (JP) 2001-08-29 EP disclosed
US-6054624-A USEFUL AS THE STARTING MATERIALS FOR PRODUCING PESTICIDES, DRUGS AND THE LIKE NIPPON SODA CO., LTD. (JP) 2000-04-25 US disclosed
US-6054605-A CHEMICAL INTERMEDIATE FOR DRUGS, PESTICIDES NIPPON SODA CO., LTD. (JP) 2000-04-25 US disclosed
US-5977414-A 2,3-Dihalogeno-6-trifluoromethylbenzene derivatives and processes for the preparation thereof NIPPON SODA CO., LTD. (JP) 1999-11-02 US disclosed
EP-0881207-A1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NIPPON SODA CO., LTD. (JP) 1998-12-02 EP disclosed
EP-0847977-A1 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME NIPPON SODA CO., LTD. (JP) 1998-06-17 EP disclosed