Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.32 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9344684 | 0.84 | ALDH1A1 (0.45) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL30480764 | 0.82 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL7926449 | 0.82 | KIF11 (0.42) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL613749 | 0.82 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL8401545 | 0.81 | KIF11 (0.34) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL8404988 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL658325 | 0.81 | KMT2A (0.38) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL6723976 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL9340518 | 0.76 | NOTUM (0.39) | ALDH1A1KMT2AMEN1TDP1KIF11 | |
| SCHEMBL909840 | 0.76 | MEN1 (0.61) | ALDH1A1KMT2AMEN1TDP1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-10095742-A | — | — | None | — | — | JP | disclosed |
| US-12012466-B2 | Peptide macrocycles against Acinetobacter baumannii | HOFFMANN-LA ROCHE INC. (US) | 2024-06-18 | — | — | US | disclosed |
| CN-110366556-B | Antibacterial peptide macrocyclic compounds and uses thereof | 豪夫迈·罗氏有限公司 | 2024-01-05 | — | — | CN | disclosed |
| US-20220411468-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN-LA ROCHE INC. (US) | 2022-12-29 | — | — | US | disclosed |
| EP-3609904-B1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | HOFFMANN LA ROCHE (CH) | 2022-11-30 | — | — | EP | disclosed |
| CN-108350028-B | Peptide macrocycles against Acinetobacter baumannii | 豪夫迈·罗氏有限公司 | 2021-12-07 | — | — | CN | disclosed |
| US-11066443-B2 | Anti-bacterial peptide macrocycles and use thereof | HOFFMANN-LA ROCHE INC. (US) | 2021-07-20 | — | — | US | disclosed |
| EP-3368544-B1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN LA ROCHE (CH) | 2020-06-17 | — | — | EP | disclosed |
| EP-3609904-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | H. Hoffnabb-La Roche Ag (CH) | 2020-02-19 | — | — | EP | disclosed |
| US-20200040031-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | HOFFMANN LA ROCHE (US) | 2020-02-06 | — | — | US | disclosed |
| US-20140336187-A1 | METHODS FOR TREATING LEISHMANIASIS | HOWARD UNIVERSITY | 2014-11-13 | — | — | US | disclosed |
| WO-2013074930-A1 | METHODS FOR TREATING LEISHMANIASIS | HOWARD UNIVERSITY (US) | 2013-05-23 | — | — | WO | disclosed |
| WO-2013016661-A1 | METHOD FOR INHIBITING TRYPANSOMA CRUZI | HOWARD UNIVERSITY (US) | 2013-01-31 | — | — | WO | disclosed |
| EP-0847977-B1 | 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | NIPPON SODA CO (JP) | 2001-08-29 | — | — | EP | disclosed |
| US-6054605-A | CHEMICAL INTERMEDIATE FOR DRUGS, PESTICIDES | NIPPON SODA CO., LTD. (JP) | 2000-04-25 | — | — | US | disclosed |
| US-6054624-A | USEFUL AS THE STARTING MATERIALS FOR PRODUCING PESTICIDES, DRUGS AND THE LIKE | NIPPON SODA CO., LTD. (JP) | 2000-04-25 | — | — | US | disclosed |
| US-5977414-A | 2,3-Dihalogeno-6-trifluoromethylbenzene derivatives and processes for the preparation thereof | NIPPON SODA CO., LTD. (JP) | 1999-11-02 | — | — | US | disclosed |
| EP-0881207-A1 | 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NIPPON SODA CO., LTD. (JP) | 1998-12-02 | — | — | EP | disclosed |
| EP-0847977-A1 | 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBENZENE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | NIPPON SODA CO., LTD. (JP) | 1998-06-17 | — | — | EP | disclosed |
| JP-H1095742-A | 2,3-DIHALOGENO-6-TRIFLUOROMETHYLBEZALDEHYDE AND ITS PRODUCTION | NIPPON SODA CO LTD | 1998-04-14 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066443-B2 | Anti-bacterial peptide macrocycles and use thereof | CFTR, VIP, NGLY1 | ALDH1A1 4791/4885KMT2A 4556/4885MEN1 635/4885 |
| US-20220411468-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | VIP, ARG1, CX3CR1 | ALDH1A1 4290/4885KMT2A 4041/4885MEN1 650/4885 |
| US-12012466-B2 | Peptide macrocycles against Acinetobacter baumannii | VIP, ARG1, CX3CR1 | ALDH1A1 4290/4885KMT2A 4041/4885MEN1 650/4885 |
| US-20140336187-A1 | METHODS FOR TREATING LEISHMANIASIS | LSS, CYP51A1, NQO1 | ALDH1A1 911/4885KMT2A 768/4885MEN1 3886/4885 |
| US-20200040031-A1 | ANTI-BACTERIAL PEPTIDE MACROCYCLES AND USE THEREOF | CFTR, VIP, NGLY1 | ALDH1A1 4791/4885KMT2A 4556/4885MEN1 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.