Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | XDH | P47989 | 3/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29600264 | 0.81 | MAPT (0.47) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| SCHEMBL447389 | 0.72 | MAPT (0.84) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| Hydrochloric Acid SCHEMBL7296117 | 0.71 | MAPT (0.81) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| SCHEMBL22144 | 0.68 | MAPT (1.00) | MAPTALDH1A1HSD17B10HPGDALOX15 | |
| Uric Acid SCHEMBL2786719 | 0.68 | MAPT (0.53) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| SCHEMBL932949 | 0.68 | MAPT (0.53) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| SCHEMBL2837685 | 0.68 | MAPT (0.53) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| SCHEMBL932609 | 0.68 | MAPT (0.53) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| SCHEMBL29737686 | 0.68 | MAPT (0.53) | MAPTALDH1A1HSD17B10CYP3A4HPGD | |
| SCHEMBL740931 | 0.68 | MAPT (0.53) | MAPTALDH1A1HSD17B10CYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221874-B1 | 7-CYCLIC-SUBSTITUTED SULFONYL-3,7-DIHYDRO-PURINE-2, 6-DIONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION | 2001-04-24 | — | — | US | disclosed |