Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 7/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17276076 | 0.81 | ACACB (0.47) | HCRTR1HCRTR2GRM5CYP11B1CYP11B2 | |
| SCHEMBL7320740 | 0.81 | ACACB (0.47) | GRM5CYP11B1CYP11B2CYP19A1ALDH1A1 | |
| SCHEMBL4929558 | 0.80 | ACACB (0.41) | HCRTR1HCRTR2GRM5CYP11B1CYP11B2 | |
| SCHEMBL13571061 | 0.79 | EPHX2 (0.44) | HCRTR1HCRTR2CLK4GRM5CYP11B1 | |
| SCHEMBL202446 | 0.79 | ALDH1A1 (0.48) | ALDH1A1ACACBCYP2D6 | |
| SCHEMBL4930416 | 0.79 | GABRG2 (0.49) | HCRTR1HCRTR2CLK4GRM5CYP11B1 | |
| SCHEMBL19999901 | 0.76 | GRM5 (0.38) | HCRTR1HCRTR2CLK4GRM5CYP11B1 | |
| SCHEMBL4937003 | 0.75 | MCHR1 (0.36) | HCRTR1HCRTR2GRM5CYP11B1CYP11B2 | |
| SCHEMBL446432 | 0.75 | SCN7A (0.52) | — | |
| SCHEMBL23162650 | 0.75 | CYP11B1 (0.35) | HCRTR1HCRTR2GRM5CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228868-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-08 | — | — | US | disclosed |