SCHEMBL7921101

SCHEMBL7921101

CCOC(=O)COc1ccc(CSCCNS(=O)(=O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.57
TSHR P16473 4/20 0.57
TP53 P04637 1/20 0.57
ALOX15 P16050 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.55
GAA P10253 2/20 0.55
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
NPSR1 Q6W5P4 1/20 0.51
POLB P06746 1/20 0.51
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
HTT P42858 1/20 0.49
MAPT P10636 1/20 0.49
SGMS1 Q86VZ5 1/20 0.48
NPY1R P25929 1/20 0.48
LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7921088 0.90 ALDH1A1 (0.63) ALDH1A1TSHRTP53ALOX15SMN1; SMN2
SCHEMBL9129860 0.86 TSHR (0.65) ALDH1A1TSHRTP53ALOX15SMN1; SMN2
SCHEMBL7924019 0.86 TBXA2R (0.58) ALDH1A1SMN1; SMN2GAACYP2C9CYP2C19
SCHEMBL7911907 0.86 ALDH1A1 (0.59) ALDH1A1TSHRTP53ALOX15SMN1; SMN2
SCHEMBL7918882 0.81 TBXA2R (0.59) ALDH1A1TSHRTP53ALOX15SMN1; SMN2
SCHEMBL8443300 0.80 SGMS1 (0.53) ALDH1A1TSHRTP53ALOX15SMN1; SMN2
SCHEMBL11372605 0.78 ALDH1A1 (0.67) ALDH1A1TSHRTP53ALOX15SMN1; SMN2
SCHEMBL11379124 0.77 ALDH1A1 (0.68) ALDH1A1TSHRTP53ALOX15SMN1; SMN2
SCHEMBL7918875 0.77 GAA (0.44) ALDH1A1TP53SMN1; SMN2GAACYP2C9
SCHEMBL9778016 0.76 SMN1; SMN2 (0.58) ALDH1A1TSHRTP53ALOX15SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0811375-B1 GLUTAMIC ACID RECEPTOR AGONIST NIPPON SUISAN KAISHA LTD (JP) 2001-01-03 EP disclosed
US-5955505-A TREATING NERVE DEGENERATIVE DISORDERS NIPPON SUISAN KAISHA, LTD. (JP) 1999-09-21 US disclosed
EP-0811375-A1 GLUTAMIC ACID RECEPTOR AGONIST NIPPON SUISAN KAISHA, LTD. (JP) 1997-12-10 EP disclosed
EP-0469901-B1 Sulfonamide derivatives TAISHO PHARMACEUTICAL CO LTD (JP) 1994-10-19 EP disclosed
US-5189211-A Thromboxane A2 antagonists TAISHO PHARMACEUTICAL CO., LTD. (JP) 1993-02-23 US disclosed
EP-0469901-A1 Sulfonamide derivatives TAISHO PHARMACEUTICAL CO. LTD (JP) 1992-02-05 EP disclosed