Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 16/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 10/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917963 | 0.91 | BACE1 (0.43) | MEN1KMT2ABACE1BACE2KCNH2 | |
| SCHEMBL7918038 | 0.91 | BACE1 (0.43) | MEN1KMT2ABACE1BACE2KCNH2 | |
| SCHEMBL7924845 | 0.88 | CYP1A2 (0.42) | BACE1BACE2 | |
| SCHEMBL7913188 | 0.86 | BACE1 (0.39) | KMT2ABACE1BACE2KCNH2 | |
| SCHEMBL7920108 | 0.79 | BACE1 (0.45) | BACE1BACE2KCNH2 | |
| SCHEMBL7921890 | 0.77 | BACE1 (0.33) | BACE1BACE2KCNH2 | |
| SCHEMBL7920091 | 0.76 | CYP1A2 (0.49) | BACE1KCNH2 | |
| SCHEMBL7918102 | 0.74 | HTT (0.34) | BACE1BACE2KCNH2 | |
| SCHEMBL7918363 | 0.73 | TAAR1 (0.51) | MEN1KMT2ABACE1 | |
| SCHEMBL7919840 | 0.73 | TAAR1 (0.51) | MEN1KMT2ABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |