Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 12/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924845 | 0.88 | CYP1A2 (0.42) | BACE1BACE2ALDH1A1 | |
| SCHEMBL7921968 | 0.86 | MEN1 (0.42) | BACE1BACE2KMT2AKCNH2 | |
| SCHEMBL7920108 | 0.79 | BACE1 (0.45) | BACE1BACE2KCNH2 | |
| SCHEMBL7918038 | 0.77 | BACE1 (0.43) | BACE1BACE2KMT2AKCNH2 | |
| SCHEMBL7917963 | 0.77 | BACE1 (0.43) | BACE1BACE2KMT2AKCNH2 | |
| SCHEMBL7913192 | 0.77 | ROCK2 (0.34) | BACE1BACE2 | |
| SCHEMBL7920091 | 0.76 | CYP1A2 (0.49) | BACE1KCNH2 | |
| SCHEMBL12377509 | 0.73 | ALDH1A1 (0.41) | POLBKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL7919909 | 0.72 | TAAR1 (0.34) | BACE1 | |
| SCHEMBL7921890 | 0.72 | BACE1 (0.33) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |