SCHEMBL7922055

SCHEMBL7922055

Clc1cncc(C2=CCCNC2)n1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 0.47
CHRM3 P20309 2/20 0.47
HTR2A P28223 8/20 0.39
HTR2C P28335 3/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
HTR1A P08908 1/20 0.39
CYP2C9 P11712 1/20 0.39
HPGD P15428 1/20 0.39
CYP2C19 P33261 1/20 0.39
KMT2A Q03164 1/20 0.39
HSD17B10 Q99714 1/20 0.39
ADRA2A P08913 1/20 0.35
ADRA2B P18089 1/20 0.35
HTR2B P41595 2/20 0.35
CHRM4 P08173 1/20 0.34
CHRM5 P08912 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9458794 0.80 CHRM2 (0.47) CHRM2CHRM3HTR2AHTR2CADRA2A
SCHEMBL169474 0.77 HTR2A (0.41) CHRM2CHRM3HTR2AHTR2CMEN1
SCHEMBL25243637 0.74 TDP1 (0.39) HTR2AHTR2CKDM4EMEN1ALDH1A1
SCHEMBL25729525 0.72 TDP1 (0.45) HTR2AHTR2CKDM4EMEN1ALDH1A1
SCHEMBL13490378 0.70 HTR2A (0.47) CHRM2CHRM3HTR2AHTR2CADRA2A
SCHEMBL8716712 0.66 CHRM2 (0.45) CHRM2CHRM3HTR2AHTR2CADRA2A
SCHEMBL21193038 0.64 CHRM2 (0.44) CHRM2CHRM3HTR2AHTR2CADRA2A
SCHEMBL10699144 0.64 CHRM2 (0.41) CHRM2CHRM3
SCHEMBL12043351 0.64 CHRM2 (1.00) CHRM2CHRM3HTR2AHTR2CADRA2A
SCHEMBL31334412 0.64 HTR2A (0.42) CHRM2CHRM3HTR2AHTR2CKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0871445-A4 COMPOSITION FOR TREATING PAIN LILLY CO ELI (US) 2001-01-10 EP disclosed
EP-0783304-A4 METHOD FOR TREATING ANXIETY LILLY CO ELI (US) 1999-01-27 EP disclosed
EP-0871445-A1 COMPOSITION FOR TREATING PAIN ELI LILLY AND COMPANY (US) 1998-10-21 EP disclosed
EP-0783304-A1 METHOD FOR TREATING ANXIETY ELI LILLY AND COMPANY (US) 1997-07-16 EP disclosed
WO-1997020561-A1 COMPOSITION FOR TREATING PAIN ELI LILLY AND COMPANY (US) 1997-06-12 WO disclosed
US-5574053-A Method for treating anxiety ELI LILLY AND COMPANY (US) 1996-11-12 US disclosed
US-5574029-A Method for treating anxiety ELI LILLY AND COMPANY (US) 1996-11-12 US disclosed
US-5574028-A SEDATIVES ELI LILLY AND COMPANY (US) 1996-11-12 US disclosed
WO-1996013261-A1 METHOD FOR TREATING ANXIETY ELI LILLY AND COMPANY (US) 1996-05-09 WO disclosed