Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 10/20 | 0.40 |
| ▸ | HTR2C | P28335 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 5/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21192981 | 0.68 | ADRA2A (0.44) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL10699144 | 0.67 | CHRM2 (0.41) | CHRM2CHRM3 | |
| SCHEMBL7617737 | 0.67 | CHRM1 (0.50) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL3691609 | 0.67 | CHRM2 (0.41) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL13490562 | 0.66 | HTR2A (0.47) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL9458794 | 0.66 | CHRM2 (0.47) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL7617483 | 0.66 | CHRM1 (0.49) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL8405098 | 0.66 | CHRM2 (0.66) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL9342819 | 0.66 | CHRM2 (0.43) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL7922055 | 0.66 | CHRM2 (0.47) | CHRM2CHRM3HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712297-A | COGNITION ACTIVATORS; ALZHEIMER*S DISEASE | NOVO NORDISK A/S (DK) | 1998-01-27 | — | — | US | disclosed |
| US-5559138-A | Method of Treating Glaucoma Using Oxadiazolyl or Thiadiazolyl Tetrahydropyridines | NOVO NORDISK A/S (DK) | 1996-09-24 | — | — | US | disclosed |
| EP-0384288-B1 | Piperidine compounds and their preparation and use | NOVO NORDISK AS (DK) | 1995-05-24 | — | — | EP | disclosed |
| US-5328925-A | Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1994-07-12 | — | — | US | disclosed |
| US-5284859-A | Analgesics, Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-02-08 | — | — | US | disclosed |
| US-5264444-A | Cognition activators | NOVO NORDISK A/S (DK) | 1993-11-23 | — | — | US | disclosed |
| US-5260311-A | Cognition activators, analgesics for sever pain, glaucoma treatment | NOVO NORDISK A/S (DK) | 1993-11-09 | — | — | US | disclosed |
| US-5041455-A | Stimulants of cognitive function in mammals | NOVO NORDISK A/S (DK) | 1991-08-20 | — | — | US | disclosed |
| EP-0384288-A2 | Piperidine compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1990-08-29 | — | — | EP | disclosed |