Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28131668 | 0.74 | MCL1 (0.37) | NR1H4TP53 | |
| SCHEMBL7913508 | 0.71 | ADORA2A (0.38) | NPSR1GAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL27494152 | 0.71 | NOTUM (0.45) | LMNATSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28983710 | 0.68 | GRIA1 (0.35) | TSHRNPC1SMN1; SMN2RAB9ACASP3 | |
| Methane SCHEMBL28094000 | 0.67 | GRIA1 (0.34) | NPC1SMN1; SMN2RAB9ACASP3SENP8 | |
| SCHEMBL7833158 | 0.66 | CYP1A2 (0.37) | TSHRALDH1A1HSD17B10TP53CYP1A2 | |
| SCHEMBL28430350 | 0.65 | ALDH1A1 (0.34) | TSHRALDH1A1SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL28963193 | 0.65 | NPC1 (0.32) | TSHRNPC1SMN1; SMN2RAB9ACASP3 | |
| SCHEMBL7922195 | 0.65 | ADORA2A (0.37) | NR1H4NPSR1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8775987 | 0.64 | MYC (0.33) | LMNAALDH1A1AKR1B1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001766-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2001-04-04 | — | — | EP | disclosed |
| EP-1001766-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001127-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |