Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 17/20 | 0.48 |
| ▸ | PSMB11 | A5LHX3 | 6/20 | 0.48 |
| ▸ | PSMA7 | O14818 | 6/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 6/20 | 0.48 |
| ▸ | PSMA1 | P25786 | 6/20 | 0.48 |
| ▸ | PSMA2 | P25787 | 6/20 | 0.48 |
| ▸ | PSMA3 | P25788 | 6/20 | 0.48 |
| ▸ | PSMA4 | P25789 | 6/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 6/20 | 0.48 |
| ▸ | PSMB9 | P28065 | 6/20 | 0.48 |
| ▸ | PSMA5 | P28066 | 6/20 | 0.48 |
| ▸ | PSMB4 | P28070 | 6/20 | 0.48 |
| ▸ | PSMB6 | P28072 | 6/20 | 0.48 |
| ▸ | PSMB10 | P40306 | 6/20 | 0.48 |
| ▸ | PSMB3 | P49720 | 6/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 6/20 | 0.48 |
| ▸ | PSMA6 | P60900 | 6/20 | 0.48 |
| ▸ | PSMA8 | Q8TAA3 | 6/20 | 0.48 |
| ▸ | PSMB7 | Q99436 | 6/20 | 0.48 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19790136 | 0.97 | PSMB5 (0.49) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL12279029 | 0.97 | PSMB5 (0.49) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL7923404 | 0.84 | PSEN1 (0.46) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19382403 | 0.84 | PSEN1 (0.62) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL3134127 | 0.84 | PSEN1 (0.62) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL7921796 | 0.82 | PSEN1 (0.40) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7922394 | 0.81 | PSMB5 (0.48) | PSMB5PSMB1PSMB2PSEN1PSEN2 | |
| SCHEMBL19381917 | 0.81 | PSMB5 (0.48) | PSMB5PSMB1PSMB2PSEN1PSEN2 | |
| SCHEMBL2506122 | 0.81 | PSEN1 (0.63) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL7927527 | 0.80 | NPY5R (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346882-B1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | MILLENNIUM PHARM INC (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2010036357-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-04-01 | — | — | WO | disclosed |