Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 16/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.41 |
| ▸ | GNPAT | O15228 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19381917 | 1.00 | PSMB5 (0.48) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7922233 | 0.89 | PSMB5 (0.39) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7922390 | 0.83 | PSEN1 (0.35) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3140881 | 0.83 | PSMB5 (0.71) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7923404 | 0.82 | PSEN1 (0.46) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7922252 | 0.81 | PSMB5 (0.48) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7927527 | 0.80 | NPY5R (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL19381924 | 0.80 | PSMB5 (0.40) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7921796 | 0.79 | PSEN1 (0.40) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12279029 | 0.78 | PSMB5 (0.49) | PSMB5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036357-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-04-01 | — | — | WO | disclosed |