Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.36 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922652 | 0.75 | PTGS1 (0.40) | HTTSMN1; SMN2L3MBTL1KMT2AKDM4E | |
| SCHEMBL7012005 | 0.71 | PLK1 (0.47) | LTA4HSLC6A4SAE1UBA2SMN1; SMN2 | |
| SCHEMBL31092472 | 0.70 | ALDH1A1 (0.53) | HTTSMN1; SMN2L3MBTL1POLBKMT2A | |
| SCHEMBL1425001 | 0.65 | LTA4H (0.81) | LTA4HSLC6A4SAE1UBA2SMN1; SMN2 | |
| SCHEMBL25986524 | 0.65 | LTA4H (0.81) | LTA4HSLC6A4SAE1UBA2SMN1; SMN2 | |
| SCHEMBL27884 | 0.65 | LTA4H (0.81) | LTA4HSLC6A4SAE1UBA2SMN1; SMN2 | |
| SCHEMBL21994566 | 0.64 | LTA4H (0.59) | LTA4HSAE1UBA2SMN1; SMN2IDO1 | |
| SCHEMBL12776284 | 0.63 | SLC6A4 (0.60) | LTA4HSLC6A4L3MBTL1KMT2AMEN1 | |
| Ammonia Solution, Strong SCHEMBL20919857 | 0.63 | LTA4H (0.77) | LTA4HSLC6A4SAE1UBA2SMN1; SMN2 | |
| SCHEMBL16383175 | 0.62 | SLC6A4 (0.69) | LTA4HSLC6A4L3MBTL1IDO1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135365-A1 | 4-3-SUBSTITUTED-AMINO-CYCLOBUT-3-ENE-1,2-DIONES AND USE FOR INFLUENCING SMOOTH MUSCLE CONTRACTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034230-A1 | 4-3-SUBSTITUTED-AMINO-CYCLOBUT-3-ENE-1,2-DIONES AND USE FOR INFLUENCING SMOOTH MUSCLE CONTRACTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | disclosed |