SCHEMBL7922497

SCHEMBL7922497

CN1CN/C(=N/C#N)N(Cc2ccc(Cl)nc2)C1

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 3/20 0.53
MEN1 O00255 1/20 0.53
KMT2A Q03164 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
CHRNB2 P17787 2/20 0.48
CHRNA4 P43681 2/20 0.48
LMNA P02545 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CHRNA1 P02708 2/20 0.40
CHRNA3 P32297 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
ALDH1A1 P00352 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
AR P10275 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7506849 1.00 CHRNA7 (0.53) CHRNA7MEN1KMT2ATDP1CHRNB2
SCHEMBL19975726 0.82 CHRNA7 (0.61) CHRNA7MEN1KMT2ATDP1CHRNB2
SCHEMBL5833216 0.82 CHRNA7 (0.61) CHRNA7MEN1KMT2ATDP1CHRNB2
SCHEMBL5833213 0.82 CHRNA7 (0.61) CHRNA7MEN1KMT2ATDP1CHRNB2
SCHEMBL7507154 0.80 CHRNB2 (0.50) CHRNA7CHRNB2CHRNA4LMNAL3MBTL1
SCHEMBL7507162 0.80 CHRNB2 (0.50) CHRNA7CHRNB2CHRNA4LMNAL3MBTL1
SCHEMBL5833743 0.79 CHRNA7 (0.58) CHRNA7MEN1KMT2ATDP1CHRNB2
SCHEMBL5833746 0.74 CHRNA7 (0.52) CHRNA7MEN1KMT2ATDP1CHRNB2
SCHEMBL675952 0.70 CHRNA7 (0.61) CHRNA7MEN1KMT2ATDP1CHRNB2
SCHEMBL5833965 0.70 MEN1 (0.44) CHRNA7MEN1KMT2ATDP1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5032589-A Insecticidal heterocyclic compounds NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1991-07-16 US claimed
US-6232309-B1 2-CHLOROPYRIDINE OR 2-CHLOROTHIAZOLE DERIVATIVES OF HETEROCYCLIC COMPOUNDS USED AS PESTICIDES NIHON BAYER AGROCHEM K.K. (JP) 2001-05-15 US disclosed
US-5719146-A AGRICULTURE; FORESTRY; STORAGE; HYGIENE NIHON BAYER AGROCHEM K.K. (JP) 1998-02-17 US disclosed
EP-0386565-B1 Heterocyclic compounds BAYER AGROCHEM KK (JP) 1994-01-12 EP disclosed
US-5034524-A Insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1991-07-23 US disclosed
US-5032589-A Insecticidal heterocyclic compounds NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1991-07-16 US disclosed
EP-0386565-A1 Heterocyclic compounds NIHON BAYER AGROCHEM K.K. (JP) 1990-09-12 EP disclosed