Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.57 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.57 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 4/20 | 0.44 |
| ▸ | PLG | P00747 | 3/20 | 0.44 |
| ▸ | PLAT | P00750 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PEPD | P12955 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999045 | 0.85 | F2 (0.59) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL24891830 | 0.83 | KMT2A (0.64) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| 4-Guanidino-Benzoic Acid SCHEMBL211005 | 0.83 | F2 (0.57) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| Hydrochloric Acid SCHEMBL11226180 | 0.83 | F2 (0.57) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7913893 | 0.83 | F2 (0.57) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL1996992 | 0.82 | F2 (0.50) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6931409 | 0.82 | MAPT (0.56) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| 4-Guanidino-Benzoic Acid SCHEMBL22127093 | 0.82 | F2 (0.55) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| 4-Guanidino-Benzoic Acid SCHEMBL11123754 | 0.82 | F2 (0.55) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL2782636 | 0.82 | F2 (0.55) | F2PRSS1PRSS2PRSS3TMPRSS6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821689-B1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | DRUG INNOVATION & DESIGN INC (US) | 2001-07-04 | — | — | EP | claimed |
| EP-0821689-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | Drug Innovation & Design, Inc. (US) | 1998-02-04 | — | — | EP | claimed |
| US-5659061-A | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities | DRUG INNOVATION & DESIGN, INC. (US) | 1997-08-19 | — | — | US | claimed |
| WO-1996033198-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | DRUG INNOVATION & DESIGN, INC. (US) | 1996-10-24 | — | — | WO | claimed |
| EP-0821689-B1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | DRUG INNOVATION & DESIGN INC (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-0821689-B1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | DRUG INNOVATION & DESIGN INC (US) | 2001-07-04 | — | — | EP | disclosed |
| EP-0821689-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | Drug Innovation & Design, Inc. (US) | 1998-02-04 | — | — | EP | disclosed |
| EP-0821689-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | Drug Innovation & Design, Inc. (US) | 1998-02-04 | — | — | EP | disclosed |
| US-5659061-A | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities | DRUG INNOVATION & DESIGN, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| US-5659061-A | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities | DRUG INNOVATION & DESIGN, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1996033198-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | DRUG INNOVATION & DESIGN, INC. (US) | 1996-10-24 | — | — | WO | disclosed |
| WO-1996033198-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | DRUG INNOVATION & DESIGN, INC. (US) | 1996-10-24 | — | — | WO | disclosed |