Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26530446 | 0.77 | IDO1 (0.46) | IDO1AGXTGAAACHEKDM4E | |
| SCHEMBL13973319 | 0.74 | IDO1 (0.46) | IDO1AGXTGAAACHEKDM4E | |
| SCHEMBL13965845 | 0.74 | ACHE (0.45) | IDO1AGXTGAAACHEKDM4E | |
| SCHEMBL19041058 | 0.74 | HTT (0.51) | NPSR1KDM4ESMN1; SMN2HTR2C | |
| SCHEMBL12801239 | 0.73 | IDO1 (0.42) | IDO1AGXTGAAMEN1KMT2A | |
| SCHEMBL5121261 | 0.73 | MAOB (0.44) | IDO1AGXTACHERIPK1 | |
| SCHEMBL6077476 | 0.73 | IDO1 (0.48) | IDO1AGXTGAAMEN1KMT2A | |
| SCHEMBL7922884 | 0.73 | IDO1 (0.48) | IDO1AGXTGAAMEN1KMT2A | |
| SCHEMBL7920951 | 0.72 | IDO1 (0.41) | IDO1AGXTGAAACHEKDM4E | |
| SCHEMBL4630473 | 0.71 | ACHE (0.48) | IDO1AGXTGAAL3MBTL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194461-B1 | USEFUL AS MEDICAMENT FOR TREATING RETINAL DEGENERATIVE DISORDERS; ALPHA-(2,4-DIFLUOROPHENYL)-N-T-BUTYLNITRONE, AND CORRESPONDING AMINES WHICH WOULD BE CONVERTED IN VIVO TO THE NITRONE, FOR EXAMPLE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-02-27 | — | — | US | disclosed |
| EP-0945426-A1 | NITRONE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-29 | — | — | EP | disclosed |