Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.33 |
| ▸ | RARG | P13631 | 10/20 | 0.33 |
| ▸ | RARB | P10826 | 9/20 | 0.33 |
| ▸ | RXRB | P28702 | 7/20 | 0.33 |
| ▸ | RXRG | P48443 | 6/20 | 0.33 |
| ▸ | RARA | P10276 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7922869 | 1.00 | RXRA (0.33) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL7922871 | 0.70 | RXRA (0.39) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL6037056 | 0.70 | RXRA (0.34) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL6037052 | 0.70 | RXRA (0.34) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL8308916 | 0.70 | RXRA (0.48) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL6917353 | 0.67 | CYP3A4 (0.46) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL6037045 | 0.66 | RXRA (0.52) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL6037047 | 0.66 | RXRA (0.52) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL8806906 | 0.66 | RXRA (0.34) | RXRARARGRARBRXRBRXRG | |
| SCHEMBL8806908 | 0.66 | RXRA (0.34) | RXRARARGRARBRXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143953-A3 | METHOD OF INHIBITING ANGIOGENESIS | Genentech, Inc. (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1143953-A2 | METHOD OF INHIBITING ANGIOGENESIS | Genentech, Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000030628-A2 | METHOD OF INHIBITING ANGIOGENESIS | GENENTECH, INC. (US) | 2000-06-02 | — | — | WO | disclosed |