Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.39 |
| ▸ | RXRG | P48443 | 10/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.36 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | RARA | P10276 | 6/20 | 0.35 |
| ▸ | RARG | P13631 | 5/20 | 0.35 |
| ▸ | RARB | P10826 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 7/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6037047 | 0.84 | RXRA (0.52) | RXRARXRGRARARARGRARB | |
| SCHEMBL6037045 | 0.84 | RXRA (0.52) | RXRARXRGRARARARGRARB | |
| SCHEMBL8614789 | 0.81 | RXRA (0.36) | RXRARXRGCYP26A1CYP26B1RARA | |
| SCHEMBL8450973 | 0.79 | MPO (0.33) | RXRARXRGRXRB | |
| SCHEMBL8308916 | 0.77 | RXRA (0.48) | RXRARXRGCYP26A1CYP26B1RARA | |
| SCHEMBL6913577 | 0.71 | RXRA (0.60) | RXRARXRGRARARARGRARB | |
| SCHEMBL7922876 | 0.70 | RXRA (0.33) | RXRARXRGCYP26A1RARARARG | |
| SCHEMBL7922869 | 0.70 | RXRA (0.33) | RXRARXRGCYP26A1RARARARG | |
| SCHEMBL6037052 | 0.68 | RXRA (0.34) | RXRARXRGCYP26A1CYP26B1RARA | |
| SCHEMBL6037056 | 0.68 | RXRA (0.34) | RXRARXRGCYP26A1CYP26B1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143953-A3 | METHOD OF INHIBITING ANGIOGENESIS | Genentech, Inc. (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1143953-A2 | METHOD OF INHIBITING ANGIOGENESIS | Genentech, Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000030628-A2 | METHOD OF INHIBITING ANGIOGENESIS | GENENTECH, INC. (US) | 2000-06-02 | — | — | WO | disclosed |