Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.67 |
| ▸ | CES1 | P23141 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 6/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11370460 | 1.00 | CES2 (0.67) | CES2CES1MAPTSMN1; SMN2POLB | |
| SCHEMBL10810096 | 1.00 | CES2 (0.67) | CES2CES1MAPTSMN1; SMN2POLB | |
| SCHEMBL4711175 | 0.81 | CES2 (0.62) | CES2CES1MAPTSMN1; SMN2POLB | |
| SCHEMBL4711178 | 0.81 | CES2 (0.62) | CES2CES1MAPTSMN1; SMN2POLB | |
| SCHEMBL557152 | 0.81 | CES2 (1.00) | CES2CES1MAPTCA1CA2 | |
| SCHEMBL14507040 | 0.81 | CES2 (1.00) | CES2CES1MAPTCA1CA2 | |
| SCHEMBL11489865 | 0.80 | PARP10 (0.56) | MAPTSMN1; SMN2POLBALDH1A1PARP10 | |
| SCHEMBL11714663 | 0.80 | PARP10 (0.53) | CES2CES1MAPTSMN1; SMN2POLB | |
| SCHEMBL11714645 | 0.80 | PARP10 (0.53) | CES2CES1MAPTSMN1; SMN2POLB | |
| SCHEMBL11489871 | 0.80 | PARP10 (0.56) | MAPTSMN1; SMN2POLBALDH1A1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225463-B1 | REACTING S-AMINE COMPOUND WITH AN ALDEHYDE; REACTING WITH ACYL CHLORIDE IN PRESENCE OF TRIETHYLAMINE TO FORM DIASTEREOISOMERIC BETA-LACTAMS; SEPARATION; TREATING WITH CERIUM AMMONIUM NITRATE AND ACETONITRILE AND WATER | PHARMACHEMIE B.V. (NL) | 2001-05-01 | — | — | US | disclosed |
| EP-0933360-A1 | Synthesis of new beta-lactams | PHARMACHEMIE B.V. (NL) | 1999-08-04 | — | — | EP | disclosed |
| EP-0077983-B1 | TRIAZINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-29 | — | — | EP | disclosed |
| EP-0077983-A1 | Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-05-04 | — | — | EP | disclosed |
| US-4293552-A | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas | ELI LILLY AND COMPANY (US) | 1981-10-06 | — | — | US | disclosed |
| US-4229579-A | OPTICAL BRIGHTENERS | BAYER AKTIENGESELLSCHAFT (DE) | 1980-10-21 | — | — | US | disclosed |
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4144243-A | OPTICAL BRIGHTENERS FOR TEXTILES AND LACQUEARS | BAYER AKTIENGESELLSCHAFT (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |