Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.61 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15080215 | 0.84 | TAAR1 (0.61) | TAAR1ADRA2ABACE1ADRA2BADRA2C | |
| SCHEMBL7924157 | 0.81 | TAAR1 (0.57) | TAAR1ADRA2ABACE1 | |
| SCHEMBL7916938 | 0.80 | ADRA2A (0.59) | TAAR1ADRA2AALDH1A1ADRA2BADRA2C | |
| SCHEMBL7924515 | 0.79 | TAAR1 (0.50) | TAAR1ADRA2A | |
| SCHEMBL14712634 | 0.79 | TAAR1 (0.50) | TAAR1ADRA2A | |
| SCHEMBL7919903 | 0.79 | TAAR1 (0.55) | TAAR1ADRA2ABACE1ADRA2BADRA2C | |
| SCHEMBL7923463 | 0.79 | TAAR1 (0.55) | TAAR1ADRA2ABACE1 | |
| SCHEMBL7909294 | 0.79 | TAAR1 (0.55) | TAAR1ADRA2A | |
| SCHEMBL7920308 | 0.78 | TAAR1 (0.52) | TAAR1ADRA2ABACE1ADRA1DADRA1A | |
| SCHEMBL7923678 | 0.78 | TAAR1 (0.52) | TAAR1ADRA2ABACE1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |