SCHEMBL7923735

SCHEMBL7923735

CCOC(=O)COc1c(F)cc(S(=O)(=O)CCNS(=O)(=O)c2ccc(Cl)cc2)cc1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.45
TSHR P16473 5/20 0.43
ALDH1A1 P00352 3/20 0.43
TP53 P04637 2/20 0.43
ALOX15 P16050 1/20 0.43
CYP2C9 P11712 2/20 0.42
CYP2C19 P33261 1/20 0.42
GAA P10253 3/20 0.41
HTT P42858 2/20 0.41
POLB P06746 1/20 0.41
KMT2A Q03164 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP3A4 P08684 1/20 0.41
NFKB1 P19838 1/20 0.41
PMP22 Q01453 1/20 0.41
HIF1A Q16665 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MEN1 O00255 1/20 0.41
NPSR1 Q6W5P4 1/20 0.40
LMNA P02545 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7921034 0.86 TBXA2R (0.47) ALDH1A1TP53CYP2C9GAACYP1A2
SCHEMBL7911552 0.84 ALDH1A1 (0.61) SMN1; SMN2TSHRALDH1A1TP53ALOX15
SCHEMBL7921051 0.83 SMN1; SMN2 (0.43) SMN1; SMN2TSHRALDH1A1TP53ALOX15
SCHEMBL7911850 0.76 ALDH1A1 (0.63) SMN1; SMN2TSHRALDH1A1TP53ALOX15
SCHEMBL7919277 0.76 ALDH1A1 (0.54) SMN1; SMN2TSHRALDH1A1TP53ALOX15
SCHEMBL7918875 0.75 GAA (0.44) SMN1; SMN2ALDH1A1TP53CYP2C9GAA
SCHEMBL7918789 0.75 ALDH1A1 (0.64) SMN1; SMN2TSHRALDH1A1CYP2C9CYP2C19
SCHEMBL7924006 0.75 SMN1; SMN2 (0.61) SMN1; SMN2TSHRALDH1A1TP53ALOX15
SCHEMBL18377407 0.74 GAA (0.48) SMN1; SMN2TSHRALDH1A1CYP2C19GAA
SCHEMBL7918876 0.74 ALDH1A1 (0.74) SMN1; SMN2TSHRALDH1A1TP53ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0811375-B1 GLUTAMIC ACID RECEPTOR AGONIST NIPPON SUISAN KAISHA LTD (JP) 2001-01-03 EP disclosed
US-5955505-A TREATING NERVE DEGENERATIVE DISORDERS NIPPON SUISAN KAISHA, LTD. (JP) 1999-09-21 US disclosed
EP-0811375-A1 GLUTAMIC ACID RECEPTOR AGONIST NIPPON SUISAN KAISHA, LTD. (JP) 1997-12-10 EP disclosed
EP-0469901-B1 Sulfonamide derivatives TAISHO PHARMACEUTICAL CO LTD (JP) 1994-10-19 EP disclosed
US-5189211-A Thromboxane A2 antagonists TAISHO PHARMACEUTICAL CO., LTD. (JP) 1993-02-23 US disclosed
EP-0469901-A1 Sulfonamide derivatives TAISHO PHARMACEUTICAL CO. LTD (JP) 1992-02-05 EP disclosed