Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7923784 | 1.00 | SMN1; SMN2 (0.45) | SMN1; SMN2POLBGPR52PARP1NPC1 | |
| SCHEMBL6547170 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2POLBGPR52PARP1NPC1 | |
| SCHEMBL27622858 | 0.84 | NPC1 (0.48) | SMN1; SMN2POLBNPC1RAB9AMEN1 | |
| SCHEMBL7535000 | 0.83 | MTNR1A (0.47) | MTNR1AMTNR1B | |
| SCHEMBL6547639 | 0.81 | GPR52 (0.44) | SMN1; SMN2POLBGPR52PARP1NPC1 | |
| SCHEMBL10591207 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBGPR52PARP1NPC1 | |
| SCHEMBL6546977 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2POLBGPR52PARP1NPC1 | |
| SCHEMBL7923653 | 0.79 | ERCC5 (0.42) | SMN1; SMN2PARP1NPC1RAB9AMEN1 | |
| SCHEMBL7923651 | 0.79 | ERCC5 (0.42) | SMN1; SMN2PARP1NPC1RAB9AMEN1 | |
| SCHEMBL7917360 | 0.79 | MTNR1A (0.63) | SMN1; SMN2GPR52PARP1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174898-B1 | TREATING FILARIAE IN LYMPHATIC SYSTEM BY ADMINISTERING N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND ESTERS IN WHICH A SUBSTITUTED ALKYL CHAIN FORMS PART OF N-SUBSTITUENT AND SALTS | NOVO NORDISK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| EP-0858339-A1 | A METHOD OF TREATING FILARIAE | NOVO NORDISK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| EP-0502031-B1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND A PHARMACEUTICAL COMPOSITION | NOVO NORDISK AS (DK) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997017073-A1 | A METHOD OF TREATING FILARIAE | NOVO NORDISK A/S (DK) | 1997-05-15 | — | — | WO | disclosed |
| US-5198451-A | Treatment of epilepsy, inhibitors of gamma-aminobutyric acid uptake from synaptic cleft | NOVO NORDISK A/S (DK) | 1993-03-30 | — | — | US | disclosed |
| EP-0502031-A1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND A PHARMACEUTICAL COMPOSITION. | NOVO NORDISK AS (DK) | 1992-09-09 | — | — | EP | disclosed |
| WO-1991007389-A1 | N-SUBSTITUTED AZAHETEROCYCLIC CARBOXYLIC ACIDS AND A PHARMACEUTICAL COMPOSITION | NOVO NORDISK A/S (DK) | 1991-05-30 | — | — | WO | disclosed |