Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 17/20 | 0.77 |
| ▸ | MMP2 | P08253 | 17/20 | 0.77 |
| ▸ | MMP13 | P45452 | 13/20 | 0.77 |
| ▸ | MMP8 | P22894 | 11/20 | 0.77 |
| ▸ | MMP1 | P03956 | 3/20 | 0.67 |
| ▸ | MMP14 | P50281 | 2/20 | 0.67 |
| ▸ | MMP16 | P51512 | 2/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.67 |
| ▸ | MMP3 | P08254 | 2/20 | 0.67 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29350980 | 0.90 | MMP9 (0.80) | MMP9MMP2MMP13MMP8ADAMTS4 | |
| SCHEMBL13253256 | 0.90 | MMP9 (0.80) | MMP9MMP2MMP13MMP8ADAMTS4 | |
| SCHEMBL3468444 | 0.90 | MMP9 (0.80) | MMP9MMP2MMP13MMP8ADAMTS4 | |
| SCHEMBL3468445 | 0.90 | MMP9 (0.80) | MMP9MMP2MMP13MMP8ADAMTS4 | |
| Hydrochloric Acid SCHEMBL3158786 | 0.90 | MMP9 (0.78) | MMP9MMP2MMP13MMP8ADAMTS4 | |
| Hydrochloric Acid SCHEMBL3158778 | 0.90 | MMP9 (0.78) | MMP9MMP2MMP13MMP8ADAMTS4 | |
| Hydrochloric Acid SCHEMBL7351872 | 0.90 | MMP9 (0.78) | MMP9MMP2MMP13MMP8ADAMTS4 | |
| Hydrochloric Acid SCHEMBL7340587 | 0.88 | MMP2 (0.82) | MMP9MMP2MMP13MMP8MMP1 | |
| Hydrochloric Acid SCHEMBL7340592 | 0.88 | MMP2 (0.82) | MMP9MMP2MMP13MMP8MMP1 | |
| SCHEMBL5458647 | 0.87 | MMP9 (0.79) | MMP9MMP2MMP13MMP8MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-H1992-H1 | INHIBITION OF METALLOPROTEINASES AND TUMOR NECROSIS FACTOR CONVERTASE WHICH DEGRADE PROTEIN COMPONENTS OF EXTRACELLULAR MATRIX | AGOURON PHARMACEUTICALS, INC. | 2001-09-04 | — | — | US | disclosed |