Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.82 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9644974 | 0.86 | SIGMAR1 (0.65) | HRH3SIGMAR1KCNH2DRD2HTR2B | |
| SCHEMBL23926367 | 0.86 | SIGMAR1 (0.65) | HRH3SIGMAR1KCNH2DRD2HTR2B | |
| SCHEMBL30118922 | 0.86 | SIGMAR1 (0.65) | HRH3SIGMAR1KCNH2DRD2HTR2B | |
| SCHEMBL11260259 | 0.86 | HRH3 (0.69) | HRH3SIGMAR1KCNH2DRD2MEN1 | |
| SCHEMBL18926549 | 0.82 | LTA4H (0.59) | HRH3SIGMAR1DRD2ALDH1A1 | |
| SCHEMBL12107196 | 0.82 | SIGMAR1 (1.00) | HRH3SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL1325164 | 0.81 | SIGMAR1 (0.97) | HRH3SIGMAR1KCNH2 | |
| SCHEMBL11392174 | 0.80 | SIGMAR1 (0.79) | HRH3SIGMAR1KCNH2DRD2HTR2B | |
| SCHEMBL13284339 | 0.80 | MEN1 (0.79) | HRH3SIGMAR1DRD2HTR2BMEN1 | |
| SCHEMBL2076533 | 0.79 | MAPT (0.53) | HRH3SIGMAR1KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253734-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2010039256-A1 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |