Thioctic Acid

Thioctic Acid

SCHEMBL7924

O=C(O)CCCC[C@@H]1CCSS1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 1.00
KMT2A Q03164 2/20 1.00
TARDBP Q13148 2/20 1.00
CYP2C9 P11712 1/20 1.00
MEN1 O00255 1/20 1.00
NR1I2 O75469 1/20 1.00
ALDH1A1 P00352 1/20 1.00
LMNA P02545 1/20 1.00
POLB P06746 1/20 1.00
THRB P10828 1/20 1.00
TSHR P16473 1/20 1.00
ACHE P22303 1/20 1.00
APEX1 P27695 1/20 1.00
RECQL P46063 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
SAE1 Q9UBE0 1/20 1.00
UBA2 Q9UBT2 1/20 1.00
L3MBTL1 Q9Y468 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lipoic Acid, Alpha SCHEMBL51065 1.00 HSD17B10 (1.00) HSD17B10KMT2ATARDBPCYP2C9MEN1
Thioctic Acid SCHEMBL4611014 1.00 HSD17B10 (1.00) HSD17B10KMT2ATARDBPCYP2C9MEN1
Lipoic Acid, Alpha SCHEMBL1981737 1.00 HSD17B10 (1.00) HSD17B10KMT2ATARDBPCYP2C9MEN1
Lipoic Acid, Alpha SCHEMBL2128472 1.00 HSD17B10 (1.00) HSD17B10KMT2ATARDBPCYP2C9MEN1
SCHEMBL25257437 0.98 HSD17B10 (0.96) HSD17B10KMT2ATARDBPCYP2C9MEN1
Thioctic Acid SCHEMBL6037631 0.98 HSD17B10 (0.96) HSD17B10KMT2ATARDBPCYP2C9MEN1
Lipoic Acid, Alpha SCHEMBL6037633 0.98 HSD17B10 (0.96) HSD17B10KMT2ATARDBPCYP2C9MEN1
SCHEMBL7914749 0.98 HSD17B10 (0.96) HSD17B10KMT2ATARDBPCYP2C9MEN1
Thioctic Acid SCHEMBL8948222 0.98 HSD17B10 (0.96) HSD17B10KMT2ATARDBPCYP2C9MEN1
Lipoic Acid, Alpha SCHEMBL4898905 0.98 HSD17B10 (0.96) HSD17B10KMT2ATARDBPCYP2C9MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 73495 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122081007-A Extraction method and application of lysimachia foenum-graecum volatile oil 2026-05-26 CN claimed
CN-121379932-B Culture medium for high-density serum-free suspension culture of BHK-21 cells and application thereof Zhongsheng tianxinhe (Wuxi) Biotechnology Co.,Ltd. (CN) 2026-05-26 CN claimed
CN-122081218-A Mesenchymal stem cell serum-free medium 2026-05-26 CN claimed
CN-122081234-A Low-serum MSB1 suspension medium and chicken infectious anemia virus inactivated vaccine 2026-05-26 CN claimed
CN-122080858-A Paper-based adhesive and preparation method thereof 2026-05-26 CN claimed
CN-122059654-A Composition for preparing cement-based composite material, preparation method and application thereof 中南大学 2026-05-19 CN claimed
CN-122056386-A Moisture absorption resistant slow release microcapsule powder and preparation method and application thereof 大连医诺生物股份有限公司 2026-05-19 CN claimed
CN-122060225-A Bi-component antioxidant chitosan-based temperature-sensitive hydrogel and preparation method thereof 天津工业大学 2026-05-19 CN claimed
CN-121227082-B Dolomite compound active silica filler for engineering plastics and preparation method thereof 广西武宣华恒矿业有限公司 2026-05-19 CN claimed
CN-122060613-A Preparation method of anaerobic microbial agent for stably degrading 1, 4-dichlorobenzene 南京大学 2026-05-19 CN claimed
EP-0127012-A2 Antimutagenic agent and a method of reducing mutagenicity SUNTORY LIMITED (JP) 1984-12-05 EP claimed
US-4405648-A KNEADING WHEAT FLOUR, ASCORBIC ACID, REDUCING AGENTS AND THICKENERS, FERMENTATION, AND BAKING NISSHIN FLOUR MILLING CO., LTD. (JP) 1983-09-20 US claimed
US-4390620-A Method and composition for the detection and study of cellular activity or the like and means for applying such method AGENCE NATIONALE DE VALORISATION DE LA RECHERCHE (ANVAR) (FR) 1983-06-28 US claimed
EP-0080879-A2 Pharmaceutical composition containing interferon in stable state SUNSTAR KABUSHIKI KAISHA (JP) 1983-06-08 EP claimed
EP-0076647-A2 Culture media for cells originating from the immune system HANA Biologics Incorporated (US) 1983-04-13 EP claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed
US-4304785-A LIVER PROTECTIVE AGENTS PLC PHARMACEUTICAL LICENCES COMPANY LIMITED (CH) 1981-12-08 US claimed
US-4229435-A CONCENTRATION OF COAGULATION FACTORS BLOMBAECK BIRGER E G 1980-10-21 US claimed
US-4195998-A NONSILVER PHOTOGRAPHIC FILMS; DISULFIDE, DIAZOANTHRONE, DIAZOPHENANTHRONE, AROMATIC AZIDE, QUINONE OR CARBAZIDE PHOTOREDUCTANT EASTMAN KODAK COMPANY (US) 1980-04-01 US claimed
US-4100150-A Stabilization of interferon against mechanical stress using thioctic acid G. D. SEARLE & CO. (US) 1978-07-11 US claimed