Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3467376 | 0.90 | MAPT (0.56) | PDE10AHDAC1HDAC6MAPTHDAC3 | |
| SCHEMBL3467874 | 0.88 | HDAC6 (0.57) | HDAC1HDAC6MAPTHDAC3HDAC2 | |
| SCHEMBL3467928 | 0.85 | HDAC1 (0.60) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL3467644 | 0.83 | HDAC1 (0.52) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL3468139 | 0.83 | CNR2 (0.58) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL7912521 | 0.83 | HDAC3 (0.59) | HDAC1HDAC6MAPTHDAC3HDAC2 | |
| SCHEMBL7921598 | 0.81 | HDAC6 (0.55) | HDAC1HDAC6HDAC3HDAC2HDAC8 | |
| SCHEMBL3467483 | 0.80 | GAA (0.60) | HDAC1HDAC6MAPTHDAC3HDAC2 | |
| SCHEMBL3467448 | 0.80 | GAA (0.54) | HDAC1HDAC6MAPTHDAC3HDAC2 | |
| SCHEMBL3468407 | 0.80 | MAPT (0.56) | HDAC1HDAC6MAPTHDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010073078-A2 | HETEROCYCLIC COMPOUNDS AS HDAC INHIBITORS | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-01 | — | — | WO | disclosed |