SCHEMBL7924434

SCHEMBL7924434

Cc1c(N2CC(N)C(CN)C2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 6/20 0.38
SCN5A Q14524 1/20 0.38
POLB P06746 2/20 0.31
CHRM2 P08172 2/20 0.31
ALDH1A1 P00352 1/20 0.31
CHRM1 P11229 1/20 0.31
OPRM1 P35372 1/20 0.31
OPRD1 P41143 1/20 0.31
TOP1 P11387 2/20 0.30
NOTUM Q6P988 1/20 0.30
CACNA1F O60840 1/20 0.30
MAPK1 P28482 1/20 0.30
CACNA1D Q01668 1/20 0.30
CACNA1S Q13698 1/20 0.30
CACNA1C Q13936 1/20 0.30
DRD1 P21728 1/20 0.30
DPP4 P27487 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9052877 0.93 KCNH2 (0.38) KCNH2SCN5APOLBCHRM2ALDH1A1
SCHEMBL9052874 0.93 KCNH2 (0.38) KCNH2SCN5APOLBCHRM2ALDH1A1
Hydrochloric Acid SCHEMBL8560382 0.92 KCNH2 (0.38) KCNH2SCN5APOLBCHRM2ALDH1A1
Hydrochloric Acid SCHEMBL8560384 0.92 KCNH2 (0.38) KCNH2SCN5APOLBCHRM2ALDH1A1
Hydrochloric Acid SCHEMBL8564962 0.92 KCNH2 (0.38) KCNH2SCN5APOLBCHRM2ALDH1A1
SCHEMBL8577645 0.89 KCNH2 (0.37) KCNH2SCN5AALDH1A1
SCHEMBL8577650 0.89 KCNH2 (0.37) KCNH2SCN5AALDH1A1
SCHEMBL8577637 0.89 KCNH2 (0.37) KCNH2SCN5AALDH1A1
SCHEMBL8575780 0.89 KCNH2 (0.40) KCNH2SCN5ATOP1
Hydrochloric Acid SCHEMBL7505703 0.89 KCNH2 (0.37) KCNH2SCN5AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235751-B1 BACTERICIDES KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2001-05-22 US claimed
US-6235751-B1 BACTERICIDES KOREAN RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2001-05-22 US disclosed
EP-1003735-A1 QUINOLIZINE CARBOXYLIC ACID DERIVATIVES Korea Research Institute of Chemical Technology (KR) 2000-05-31 EP disclosed
WO-1999007696-A1 QUINOLIZINE CARBOXYLIC ACID DERIVATIVES KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1999-02-18 WO disclosed