Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 13/20 | 0.69 |
| ▸ | SLC6A2 known ✓ | P23975 | 12/20 | 0.69 |
| ▸ | SLC6A3 known ✓ | Q01959 | 12/20 | 0.69 |
| ▸ | MTOR known ✓ | P42345 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21694958 | 0.88 | SLC6A2 (0.74) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Fumaric Acid SCHEMBL7932100 | 0.81 | SLC6A4 (1.00) | SLC6A4SLC6A2SLC6A3 | |
| Ammonia Solution, Strong SCHEMBL7925131 | 0.80 | SLC6A4 (0.62) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Sertraline SCHEMBL5143430 | 0.76 | SLC6A4 (0.79) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Sertraline SCHEMBL398733 | 0.76 | SLC6A4 (0.79) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Sertraline SCHEMBL398732 | 0.76 | SLC6A4 (0.79) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Desmethylsertraline SCHEMBL259292 | 0.75 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Dasotraline SCHEMBL263142 | 0.75 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Desmethylsertraline SCHEMBL4570539 | 0.75 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 | |
| Desmethylsertraline SCHEMBL260449 | 0.75 | SLC6A2 (1.00) | SLC6A4SLC6A2SLC6A3TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268535-B1 | REACTING BENZENE SUBSTITUTED UNSATURATED CARBOXYLIC ACID IN PRESENCE OF FRIEDEL-CRAFT CATALYST WITH BENZENE COMPOUND TO FORM 3-ARYL-3-PHENYL-1-PROPANOIC ACID REACTING TO FORM 3-ARYL INDAN; REDUCING, REACTING WITH AMINE TO FORM 3-ARYLINDANAMINE | PHARM-ECO LABORATORIES, INC. | 2001-07-31 | — | — | US | disclosed |
| EP-1044184-A1 | SYNTHESIS OF 3-ARYL-1-INDANAMINES | Pharm-Eco Laboratoires, Incorporated (US) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999035119-A1 | SYNTHESIS OF 3-ARYL-1-INDANAMINES | PHARM-ECO LABORATORIES, INC. (US) | 1999-07-15 | — | — | WO | disclosed |