Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.59 |
| ▸ | MTOR | P42345 | 12/20 | 0.59 |
| ▸ | PIK3R1 | P27986 | 9/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.53 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.52 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29564396 | 0.92 | PIK3CA (0.52) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL31147112 | 0.92 | PIK3CA (0.52) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1309279 | 0.86 | PIK3CA (0.61) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1309314 | 0.82 | PIK3CA (0.57) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1311065 | 0.81 | PIK3CA (0.58) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1309070 | 0.81 | PIK3CA (0.56) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1311820 | 0.80 | LMNA (0.53) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL4972261 | 0.80 | PIK3CA (0.54) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1310118 | 0.79 | PIK3CA (0.53) | PIK3CAMTORPIK3R1PIK3CDPIK3CB | |
| SCHEMBL1309970 | 0.79 | KDM4E (0.54) | PIK3CAMTORPIK3R1PIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052569-A2 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2010-05-14 | — | — | WO | disclosed |