Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3299951 | 1.00 | BACE1 (0.43) | BACE1BACE2KCNN4HDAC4 | |
| SCHEMBL2619831 | 0.86 | BACE1 (0.39) | BACE1BACE2KCNN4HDAC4 | |
| SCHEMBL12690000 | 0.86 | BACE1 (0.39) | BACE1BACE2KCNN4HDAC4 | |
| SCHEMBL2966687 | 0.86 | BACE1 (0.39) | BACE1BACE2KCNN4HDAC4 | |
| SCHEMBL14733552 | 0.84 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL12391079 | 0.83 | MMP1 (0.35) | BACE1HDAC4 | |
| SCHEMBL17794271 | 0.82 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL22238954 | 0.82 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL9913100 | 0.80 | BACE1 (0.48) | BACE1 | |
| SCHEMBL7926929 | 0.80 | BACE1 (0.48) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038686-A1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |