Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9913100 | 1.00 | BACE1 (0.48) | BACE1DDB1CRBNGRIN1GRIN2B | |
| SCHEMBL2632348 | 0.81 | BACE1 (0.39) | BACE1GRIN1GRIN2BFFAR4CNR2 | |
| SCHEMBL3299951 | 0.80 | BACE1 (0.43) | BACE1 | |
| SCHEMBL7925285 | 0.80 | BACE1 (0.43) | BACE1 | |
| SCHEMBL12391079 | 0.77 | MMP1 (0.35) | BACE1 | |
| SCHEMBL14733552 | 0.73 | BACE1 (0.45) | BACE1 | |
| SCHEMBL7925997 | 0.71 | EPHX1 (0.39) | BACE1 | |
| SCHEMBL1936096 | 0.71 | EPHX1 (0.39) | BACE1 | |
| SCHEMBL7924087 | 0.71 | CXCR2 (0.34) | FFAR4CXCR2 | |
| SCHEMBL3300613 | 0.71 | CXCR2 (0.34) | FFAR4CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038686-A1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |