Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928302 | 0.97 | MEN1 (0.35) | KMT2AMEN1KDM4EMAPTCASP3 | |
| Hydrochloric Acid SCHEMBL7924563 | 0.88 | LMNA (0.34) | KMT2AMEN1MAPTALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL7930894 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL7927366 | 0.80 | KDM4E (0.38) | KMT2AMEN1KDM4EMAPTCASP3 | |
| Hydrochloric Acid SCHEMBL7924965 | 0.80 | MEN1 (0.34) | KMT2AMEN1KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7927362 | 0.79 | MEN1 (0.36) | KMT2AMEN1KDM4EMAPTCASP3 | |
| Hydrochloric Acid SCHEMBL7924955 | 0.79 | — | — | |
| SCHEMBL7925721 | 0.79 | MEN1 (0.35) | KMT2AMEN1KDM4EMAPTALDH1A1 | |
| SCHEMBL7924740 | 0.78 | KDM4E (0.37) | KMT2AMEN1KDM4EMAPTCASP3 | |
| SCHEMBL7919162 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0867454-B1 | POLYMERIZATION CATALYST AND PROCESS FOR PRODUCING POLYMERS | IDEMITSU KOSAN CO (JP) | 2001-03-21 | — | — | EP | disclosed |
| US-6075102-A | Polymerization catalyst and process for producing polymers | IDEMITSU KOSAN CO., LTD. (JP) | 2000-06-13 | — | — | US | disclosed |
| EP-0867454-A1 | POLYMERIZATION CATALYST AND PROCESS FOR PRODUCING POLYMERS | IDEMITSU KOSAN COMPANY LIMITED (JP) | 1998-09-30 | — | — | EP | disclosed |