Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3297854 | 0.83 | KMT2A (0.50) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL27598451 | 0.82 | KMT2A (0.53) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL2669046 | 0.80 | NQO1 (0.56) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL15483094 | 0.78 | CHRNB2 (0.45) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL17664583 | 0.77 | TSHR (0.49) | CHRNB2CHRNA4MAPT | |
| SCHEMBL17941799 | 0.77 | APP (0.48) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL20037814 | 0.77 | NUDT1 (0.45) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL103005 | 0.77 | CHRNB2 (0.44) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL7941127 | 0.77 | MAPT (0.55) | CHRNB2CHRNA4KMT2ACHRNB1CHRNB4 | |
| SCHEMBL3335244 | 0.77 | MAPT (0.64) | KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010050445-A1 | BICYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2010-05-06 | — | — | WO | disclosed |