Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1936096 | 1.00 | EPHX1 (0.39) | EPHX1ALDH1A1ALOX12GLABACE1 | |
| SCHEMBL2619975 | 0.86 | EPHX1 (0.39) | EPHX1ALDH1A1ALOX12GLANPC1 | |
| SCHEMBL16664351 | 0.77 | EPHX1 (0.42) | EPHX1ALDH1A1ALOX12GLANPC1 | |
| SCHEMBL2111012 | 0.76 | EPHX1 (0.44) | EPHX1ALDH1A1ALOX12GLANPC1 | |
| SCHEMBL9913100 | 0.71 | BACE1 (0.48) | BACE1 | |
| SCHEMBL7926929 | 0.71 | BACE1 (0.48) | BACE1 | |
| SCHEMBL14716599 | 0.71 | BACE1 (0.35) | BACE1NPC1LMNAKDM4E | |
| SCHEMBL2109978 | 0.70 | EPHX1 (0.42) | EPHX1ALDH1A1ALOX12GLANPC1 | |
| SCHEMBL6878083 | 0.70 | EPHX1 (0.40) | EPHX1ALDH1A1ALOX12GLABACE1 | |
| SCHEMBL18192949 | 0.70 | EPHX1 (0.40) | EPHX1ALDH1A1ALOX12GLANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038686-A1 | NOVEL FUSED AMINODIHYDROTHIAZINE DERIVATIVE | エーザイ・アール・アンド・ディー・マネジメント株式会社 (JP) | 2010-04-08 | — | — | WO | disclosed |