Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | THRB | P10828 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1586810 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL3931733 | 0.79 | KDM4E (0.69) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL69604 | 0.78 | KDM4E (0.67) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL30844878 | 0.78 | KDM4E (0.67) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL1587439 | 0.78 | KDM4E (0.67) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL25811506 | 0.78 | KDM4E (0.67) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL6950615 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL13401405 | 0.76 | KDM4E (0.73) | KDM4EALDH1A1THRBHPGDTDP1 | |
| Hydrochloric Acid SCHEMBL9746959 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1THRBHPGDTDP1 | |
| SCHEMBL7080072 | 0.76 | KDM4E (0.75) | KDM4EALDH1A1THRBHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228868-B1 | ANTICARCINOGENIC AND ANTITUMOR AGENTS | ABBOTT LABORATORIES | 2001-05-08 | — | — | US | disclosed |
| WO-2000006556-A1 | SUBSTITUTED OXAZOLINES AS ANTIPROLIFERATIVE AGENTS | ABBOTT LABORATORIES (US) | 2000-02-10 | — | — | WO | disclosed |